This is a Patient-Oriented Problem-Solving exercise designed to promote group learning, used in our sophomore year, as part of the Infection and Immunity course. A group of physicians with different areas of expertise, including microbiologists, immunologists, infectious disease specialists, geriatric medicine specialists, and an ethicist, was involved in the development of the package, which was successfully tested last fall. The contents are arranged into four sections that are distributed among four students that work as a group. The information in each section is different, so the members of a group need to exchange information to be able to solve the problem case. This case covers a variety of significant issues: infections in the elderly, antibiotic resistance, nosocomial infections, septic shock, and termination of life support. A multiple choice pre-test and post-test are included in the case, as well as color pictures, comments about the case, and explained answers to the questions of both tests.